If you are looking to work your calves for increased size and definition is to work them 2-3 times a week and vary between high reps and low reps and heavier weight and lighter weight. I suggest you doing pulsing exercises and different rep counts to constantly change things up. I suggest seated calve raises, donkey calve raises and standing calve raises. Check out the video for a better idea of how to do pulses and the rep counted set.
Calve exercise from Gina Aliotti on Vimeo.